NPS in LBD
Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body disease: a multimodal study
PI: Dr Rachael Lawson
BAM Co-applicant: Prof Alison Yarnall
BAM Project members: Dr Laura Wright
Background:
Neuropsychiatric symptoms (NPS) are common in Lewy body disorders (LBD) and mild cognitive impairment (MCI)
NPS are associated with poorer quality of life, greater carer burden and nursing home placement
The relationship between NPS and disease progression and their pathophysiology is currently unknown
Longitudinal data from large, well defined MCI cohorts with MR imaging data are needed to understand NPS
This study aims to:
Determine the associations between NPS and cognitive decline in MCI-LB (MCI Lewy bodies) and PD-MCI (MCI in Parkinson's disease)
Integrate data from three large cohorts of participants with MCI associated with LBD: ICICLE-PD, LewyPro and SUPErB
Determine neurocorrelates to understand the networks underpinning NPS to inform future symptom management
Integrate multimodal MRI data across the three studies including structural, diffusion tensor imaging (DTI) and resting state fMRI scans
Funder: The Lewy Body Society
Contact: Dr Rachael Lawson