NPS in LBD

Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body disease: a multimodal study

PI: Dr Rachael Lawson

BAM Co-applicant: Prof Alison Yarnall

BAM Project members: Dr Laura Wright

Background:

Neuropsychiatric symptoms (NPS) are common in Lewy body disorders (LBD) and mild cognitive impairment (MCI)
NPS are associated with poorer quality of life, greater carer burden and nursing home placement
The relationship between NPS and disease progression and their pathophysiology is currently unknown
Longitudinal data from large, well defined MCI cohorts with MR imaging data are  needed to understand NPS
A graphic indicating the usage of three cohorts
Silhouette of a person with a tangled brain, the tangle is lined to another silhouette of a head with a neat ball of wool
A graphic of two hands holding up a house with an elderly couple in
A graphic displaying neuropsychiatric symptoms such as sleep disturbance
A graphic of a bar chart with a data symbol or arrow over it
A graphic of a head with a brain fading into the air

This study aims to:

Determine the associations between NPS and cognitive decline in MCI-LB (MCI Lewy bodies) and PD-MCI (MCI in Parkinson's disease)
Integrate data from three large cohorts of participants with MCI associated with LBD: ICICLE-PD, LewyPro and SUPErB
A graphic of a brain where one half is a smooth cloud and the other displays complex neural networks
A graphic of an MRI scanner
Determine neurocorrelates to understand the networks underpinning NPS to inform future symptom management
Integrate multimodal MRI data across the three studies including structural, diffusion tensor imaging (DTI) and resting state fMRI scans

Funder: The Lewy Body Society

Contact: Dr Rachael Lawson