The Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation-PD (ICICLE-PD)
Funder: Parkinson’s UK
Chief Investigator: Professor David Burn
BAM Principal Investigators: Professor Lynn Rochester, Prof Alison Yarnall
Contact: Dr Rachael Lawson
Background & Aims
The ICICLE-PD study is a study run jointly between the University of Newcastle and the University of Cambridge.
The study aims to better understand the anatomical, biochemical and genotypic mechanisms determining the transition from Parkinson’s disease (PD) to dementia associated with PD (PDD).
Methods
Participants performed clinical and cognitive tests at each appointment, and blood samples were collected. A subset of participants also had MRI brain scans, FDG-PET scans and lumbar punctures done as part of this study.
We recruited 212 participants with PD and 99 age-matched control volunteers and invited participants to return at 18-month intervals.
Outcomes
We have published over 90 research papers from this cohort, have collaborated with colleagues nationally and internationally, and work is currently underway to continue to analyse this rich and complex data for the benefit of future clinical trials.
In doing so, we will determine clinical features associated with a high risk of incident dementia and establish putative biomarkers predictive of dementia.