Background & Aims

ICICLE-GAIT is a sub-study of ICICLE-PD (Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation – Parkinson’s Disease), which aims to better understand the mechanisms determining the transition from Parkinson’s disease (PD) to PD dementia in an incident cohort.

The study protocol involved a comprehensive evaluation of gait, balance and cognitive function, falls, and other non-motor features of Parkinson’s Disease.

The principle aim of ICICLE-GAIT is to examine the utility of gait as a surrogate marker of cognitive decline in idiopathic PD. 

Objectives

Recruitment commenced in 2010 and was completed in April 2012 with 121 people with PD participating along with 184 age-matched controls. Participants were reassessed at 18, 36, 54 and 72 month follow-up.

Outcomes

Gait data will be used to predict those at risk for cognitive decline, dementia, postural instability, and future falls.