Developing a DYNAmic MultimOdal imaging method to study gait and balance in people with Parkinson’s Disease

Funder: Parkinson’s UK

Chief investigator: Professor Lynn Rochester

Principal Investigators: Professor Lynn Rochester, Professor Nicola Pavese & Professor David J. Brooks

Contact: Dr Hilmar P. Sigurdsson & Dr Ross Wilson

Background

A graphic of an MRI scanner
A graphic of half a brain being looked at by a magnifying glass. The other half of the brain has been replaced by a group of people walking. The image indicates how we are studying how the brain controls walking 
We recently developed a new way to measure brain activity using Positron Emission Tomography (PET) and a form of glucose (FDG). This will now be used in people with Parkinson’s to understand the neural mechanisms of gait and gait impairments, and to detect network dysfunction in brain pathology.
We do not fully understand how the brain controls walking because measuring brain activity during walking is difficult.

Aims & Objectives

An infographic containing brain waves either side of a brain, an MRI scanner and a group of people walking. These 3 graphics then point to a graphic of a brain network and a graphic of a hand holding up a medical cross 
Our objective is to utilise our novel methodology to develop a comprehensive multi-model neuroimaging and behavioural profile. By doing so we will provide the basis to evaluate the efficacy of targeted therapies.

Outcomes

An infographic of a safety badge, a brain and a person. Both the brain and person graphics are split into two, each with one half displaying a tremor. 
We will demonstrate the safety and feasibility of our methodology in people with Parkinson’s, and identify alterations in brain areas and their connections during walking in people with Parkinson’s compared to healthy adults. This will help us develop treatments and rehabilitation to focus on these areas.